Demucs

Demucs is Meta's open-source music source separation model, and its Hybrid Transformer version (HT Demucs, v4) became one of the most widely used engines for splitting songs into vocals, drums, bass and other parts. Many free and paid separators, desktop apps like Ultimate Vocal Remover, and even commercial services build on it or its fine-tuned variants. You can run it from the command line on your own computer, and it runs faster with a GPU. It's released under the permissive MIT license, so developers can use it commercially.